THPO

Thpo is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. Thpo is a ligand for the product of the myeloproliferative leukemia virus oncogene.
Full Name
Thrombopoietin
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Biological Process
Biological Process cell population proliferationSource:InterPro
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication
Cellular Location
Secreted
Involvement in disease
Thrombocythemia 1 (THCYT1):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
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Anti-THPO antibodies

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Rabbit Anti-Thpo Recombinant Antibody (CBYJT-3028) (CBMAB-T2278-YJ)

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Target: Thpo
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3028
Application*: E, WB
Datasheet SDS

Rat Anti-Thpo Recombinant Antibody (CBYJT-3027) (CBMAB-T2277-YJ)

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Target: Thpo
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3027
Application*: WB, EC
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3026) (CBMAB-T2276-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3026
Application*: WB
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3025) (CBMAB-T2275-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3025
Application*: WB
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3024) (CBMAB-T2274-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3024
Application*: ED
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3023) (CBMAB-T2273-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3023
Application*: N, EC
Datasheet SDS

Rabbit Anti-THPO Recombinant Antibody (CBYJT-3022) (CBMAB-T2272-YJ)

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Target: THPO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3022
Application*: E
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3021) (CBMAB-T2271-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3021
Application*: E, WB, P, IF, IC, F
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3020) (CBMAB-T2270-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3020
Application*: WB
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3019) (CBMAB-T2269-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3019
Application*: E, F, WB
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBYJT-3018) (CBMAB-T2268-YJ)

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Target: THPO
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJT-3018
Application*: WB, E
Datasheet SDS

Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776)

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Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2869
Application*: F
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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