THPO

Thpo is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. Thpo is a ligand for the product of the myeloproliferative leukemia virus oncogene.

Thrombopoietin

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Biological Process cell population proliferationSource:InterPro
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication

Secreted

Thrombocythemia 1 (THCYT1):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.