THPO
Thpo is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. Thpo is a ligand for the product of the myeloproliferative leukemia virus oncogene.
Full Name
Thrombopoietin
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Biological Process
Biological Process cell population proliferationSource:InterPro
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication
Cellular Location
Secreted
Involvement in disease
Thrombocythemia 1 (THCYT1):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
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Anti-THPO antibodies
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CompareTarget: Thpo
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3028
Application*: E, WB
Target: Thpo
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3027
Application*: WB, EC
Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3026
Application*: WB
Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3025
Application*: WB
Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3024
Application*: ED
Target: THPO
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3023
Application*: N, EC
Target: THPO
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3022
Application*: E
Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3021
Application*: E, WB, P, IF, IC, F
Target: THPO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3020
Application*: WB
Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3019
Application*: E, F, WB
Target: THPO
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBYJT-3018
Application*: WB, E
Target: Thpo
Sensitivity: 0.0015 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: THPO
Sensitivity: 0.0012 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Thpo
Sensitivity: 0.059 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: THPO
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-353
Tag: His Tag
Target: THPO
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2869
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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