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Rabbit Anti-Thpo Recombinant Antibody (CBYJT-3028) (CBMAB-T2278-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Thpo (Thrombopoietin). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all Thpo antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYJT-3028
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Mouse Thrombopoietin/THPO protein. This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Thrombopoietin/THPO
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thrombopoietin
Introduction
Thpo is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. Thpo is a ligand for the product of the myeloproliferative leukemia virus oncogene.
Entrez Gene ID
21832
UniProt ID
P40226
Alternative Names
Ml; Tpo; Mgdf; Mpllg
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Biological Process
Biological Process cell population proliferationSource:InterPro
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication
Cellular Location
Secreted
Involvement in disease
Thrombocythemia 1 (THCYT1):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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