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Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776)


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Tested Data
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in WB
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in WB
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in FC
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in FC
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in ELISA
Mouse Anti-THPO Recombinant Antibody (CBT2869) (V2LY-0625-LY2776) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2869
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human THPO expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Thrombopoietin
Entrez Gene ID
7066
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Biological Process
Biological Process cell population proliferationSource:InterPro
Biological Process cellular response to lipopolysaccharideSource:Ensembl
Biological Process megakaryocyte developmentSource:ARUK-UCL1 Publication
Biological Process megakaryocyte differentiationSource:UniProtKB1 Publication
Biological Process positive regulation of cell population proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:UniProtKB
Biological Process positive regulation of hematopoietic stem cell proliferationSource:MGI1 Publication
Biological Process positive regulation of MAPK cascadeSource:ARUK-UCL1 Publication
Biological Process positive regulation of megakaryocyte differentiationSource:UniProtKB
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:UniProtKB
Biological Process receptor signaling pathway via STATSource:ARUK-UCL1 Publication
Biological Process thrombopoietin-mediated signaling pathwaySource:ARUK-UCL1 Publication
Cellular Location
Secreted
Involvement in disease
Thrombocythemia 1 (THCYT1):
A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes.
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For research use only. Not intended for any clinical use.

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