THSD1
Thsd1 has a broad expression in lung adult (RPKM 7.1), bladder adult (RPKM 3.0) and 25 other tissues.
Full Name
Thrombospondin, Type I, Domain 1
Function
Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
Biological Process
Focal adhesion assembly
Cellular Location
Isoform 1
Endosome membrane
Cell junction, focal adhesion
Localizes to nascent focal adhesions.
Isoform 2
Membrane
Isoform 3
Secreted
Endosome membrane
Cell junction, focal adhesion
Localizes to nascent focal adhesions.
Isoform 2
Membrane
Isoform 3
Secreted
Involvement in disease
Aneurysm, intracranial berry, 12 (ANIB12):
A form of cerebral aneurysm, a focal abnormal dilatation of a blood vessel in the brain. Berry intracranial aneurysms, also known as saccular aneurysms, have a characteristic rounded shape and account for the vast majority of intracranial aneurysms. They are the most common cause of non-traumatic subarachnoid hemorrhage, a sudden-onset disease that can lead to severe disability and death. Several risk factors such as smoking, hypertension, and excessive alcohol intake are associated with subarachnoid hemorrhage.
A form of cerebral aneurysm, a focal abnormal dilatation of a blood vessel in the brain. Berry intracranial aneurysms, also known as saccular aneurysms, have a characteristic rounded shape and account for the vast majority of intracranial aneurysms. They are the most common cause of non-traumatic subarachnoid hemorrhage, a sudden-onset disease that can lead to severe disability and death. Several risk factors such as smoking, hypertension, and excessive alcohol intake are associated with subarachnoid hemorrhage.
Topology
Extracellular: 25-413
Helical: 414-434
Cytoplasmic: 435-852
Helical: 414-434
Cytoplasmic: 435-852
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Anti-THSD1 antibodies
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Target: Thsd1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: TX17.10
Application*: F, IP, WB, IC
Target: Thsd1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3049
Application*: WB, IP, IC, F
Target: Thsd1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3048
Application*: E, WB
Target: Thsd1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3047
Application*: F, IC, IP, WB
Target: THSD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3045
Application*: F
Target: THSD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3044
Application*: F
Target: THSD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3043
Application*: F, MC
Target: THSD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3042
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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