Mouse Anti-THSD1 Recombinant Antibody (CBYJT-3043) (CBMAB-T2300-YJ)

Name: Mouse Anti-THSD1 Recombinant Antibody (CBYJT-3043)
SKU: CBMAB-T2300-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-3043

Application

FC, CyTOF

Immunogen

Mouse myeloma cell line NS0-derived recombinant human THSD1 isoform 2, Glu25-Ile361, Accession # NP_954872

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 25-361

More Infomation

Target

Full Name

Thrombospondin, Type I, Domain 1

Introduction

THSD1 contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins.

Entrez Gene ID

55901

UniProt ID

Q9NS62

Alternative Names

Thrombospondin Type 1 Domain Containing 1; Transmembrane Molecule With Thrombospondin Module; TMTSP; Thrombospondin Type-1 Domain-Containing Protein 1; Thrombospondin, Type I, Domain Containing 1; Thrombospondin, Type I, Domain 1; 4833423O18Rik; UNQ3010

Function

Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.

Biological Process

Focal adhesion assembly

Cellular Location

Isoform 1
Endosome membrane
Cell junction, focal adhesion
Localizes to nascent focal adhesions.
Isoform 2
Membrane
Isoform 3
Secreted

Involvement in disease

Aneurysm, intracranial berry, 12 (ANIB12):
A form of cerebral aneurysm, a focal abnormal dilatation of a blood vessel in the brain. Berry intracranial aneurysms, also known as saccular aneurysms, have a characteristic rounded shape and account for the vast majority of intracranial aneurysms. They are the most common cause of non-traumatic subarachnoid hemorrhage, a sudden-onset disease that can lead to severe disability and death. Several risk factors such as smoking, hypertension, and excessive alcohol intake are associated with subarachnoid hemorrhage.

Topology

Extracellular: 25-413
Helical: 414-434
Cytoplasmic: 435-852

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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