TLE2

TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to TLE2 include transcription corepressor activity. An important paralog of TLE2 is TLE1.

Full Name

Transducin Like Enhancer Of Split 2

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Biological Process

Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW

Cellular Location

Nucleus

PTM

Ubiquitinated by XIAP/BIRC4.

Anti-TLE2 antibodies

Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3292) (CBMAB-T2579-YJ)

Datasheet

SDS

Target: TLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3292

Application*: WB, F, IF

Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3293) (CBMAB-T2580-YJ)

Datasheet

SDS

Target: TLE2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-3293

Application*: WB

Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3294) (CBMAB-T2581-YJ)

Datasheet

SDS

Target: TLE2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3294

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)