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TLE2

TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to TLE2 include transcription corepressor activity. An important paralog of TLE2 is TLE1.

Full Name

Transducin Like Enhancer Of Split 2

Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Biological Process

Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW

Cellular Location

Nucleus

PTM

Ubiquitinated by XIAP/BIRC4.

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Anti-TLE2 antibodies

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Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3294) (CBMAB-T2581-YJ)

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Target: TLE2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3294

Application*: WB, IP, IF, E

Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3293) (CBMAB-T2580-YJ)

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Target: TLE2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-3293

Application*: WB

Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3292) (CBMAB-T2579-YJ)

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Target: TLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3292

Application*: WB, F, IF

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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