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Mouse Anti-TLE2 Recombinant Antibody (CBYJT-3292) (CBMAB-T2579-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3292
Antibody Isotype
IgG1
Application
WB, FC, IF

Basic Information

Immunogen
Full length human recombinant protein of human TLE2(NP_003251) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transducin Like Enhancer Of Split 2
Introduction
TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to TLE2 include transcription corepressor activity. An important paralog of TLE2 is TLE1.
Entrez Gene ID
7089
UniProt ID
Q04725
Alternative Names
Transducin Like Enhancer Of Split 2; Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila); Enhancer Of Split Groucho-Like Protein 2; ESG2; Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1); Transducin-Like Enhancer Protein 2; Enhancer Of Split Groucho 2; GRG2; ESG
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of canonical Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
PTM
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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