TNFR2

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Full Name

tumor necrosis factor receptor superfamily, member 1b

Alternative Names

p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2; Tnfrsf1b

Function

Biological Process

Biological Process agingSource:Ensembl
Biological Process aortic valve developmentSource:BHF-UCL1 Publication
Biological Process cell surface receptor signaling pathwaySource:MGI1 Publication
Biological Process cellular response to growth factor stimulusSource:Ensembl
Biological Process cellular response to lipopolysaccharideSource:MGI
Biological Process extrinsic apoptotic signaling pathwaySource:MGI1 Publication
Biological Process glial cell-neuron signalingSource:ARUK-UCL1 Publication
Biological Process immune responseSource:MGI
Biological Process inflammatory responseSource:MGI1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageSource:MGI1 Publication
Biological Process negative regulation of cardiac muscle hypertrophySource:BHF-UCL1 Publication
Biological Process negative regulation of cell deathSource:ARUK-UCL1 Publication
Biological Process negative regulation of extracellular matrix constituent secretionSource:BHF-UCL1 Publication
Biological Process negative regulation of inflammatory responseSource:MGI1 Publication
Biological Process negative regulation of neuroinflammatory responseSource:ARUK-UCL1 Publication
Biological Process negative regulation of neuron deathSource:ARUK-UCL1 Publication
Biological Process positive regulation of apoptotic process involved in morphogenesisSource:BHF-UCL1 Publication
Biological Process positive regulation of membrane protein ectodomain proteolysisSource:MGI
Biological Process positive regulation of myelinationSource:ARUK-UCL1 Publication
Biological Process positive regulation of oligodendrocyte differentiationSource:ARUK-UCL1 Publication
Biological Process pulmonary valve developmentSource:BHF-UCL1 Publication
Biological Process regulation of cytokine production involved in immune responseSource:ARUK-UCL1 Publication
Biological Process regulation of myelinationSource:ARUK-UCL1 Publication
Biological Process regulation of neuroinflammatory responseSource:ARUK-UCL1 Publication
Biological Process regulation of RNA biosynthetic processSource:ARUK-UCL1 Publication
Biological Process regulation of T cell cytokine productionSource:ARUK-UCL1 Publication
Biological Process regulation of T cell proliferationSource:ARUK-UCL1 Publication
Biological Process RNA destabilizationSource:MGI1 Publication

Cellular Location

Membrane

Topology

Extracellular: 23-258
Helical: 259-288
Cytoplasmic: 289-474