TNFRSF10A
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF10A Gene(Protein Coding) TNF Receptor Superfamily Member 10a
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.
Topology
Extracellular: 24-239
Helical: 240-262
Cytoplasmic: 263-468
Helical: 240-262
Cytoplasmic: 263-468
PTM
Palmitoylated (PubMed:19090789).
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)
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Anti-TNFRSF10A antibodies
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CompareTarget: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8F4
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 8F3
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8D1
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7F8
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7A6
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4B8
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B4
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G4
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B11
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1H7
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A8
Application*: WB, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E9
Application*: E, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E5
Application*: WB, E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S35-934
Application*: F
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4514
Application*: E
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4513
Application*: IP, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DR-4-02
Application*: F
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TR1.02
Application*: F, IH, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HS101
Application*: F, FN, IC, IP
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3652
Application*: F, IC, IF, IP, FN, IF, MC
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3651
Application*: WB, IP
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3650
Application*: WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3649
Application*: F, MC
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3648
Application*: EC, F
Target: TNFRSF10A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3647
Application*: E, ED
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DR402
Application*: IP, FN, F, IC, IF
Target: TNFRSF10A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D9S1R
Application*: F, IF, IP, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-515
Application*: F, P, N, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-N36
Application*: N, IC, IF
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-N28
Application*: WB, IP
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8Y3
Application*: F
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D46
Application*: F, IC, IP
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 32A242
Application*: IC, IF, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 32A1380
Application*: WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E8
Application*: E, WB
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1165
Application*: F, IP
Target: TNFRSF10A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3297
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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