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TNFRSF10A

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Full Name

TNFRSF10A Gene(Protein Coding) TNF Receptor Superfamily Member 10a

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).

Biological Process

Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication

Cellular Location

Cell membrane
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.

Topology

Extracellular: 24-239
Helical: 240-262
Cytoplasmic: 263-468

PTM

Palmitoylated (PubMed:19090789).
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)

Anti-TNFRSF10A antibodies

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYJT-3649) (CBMAB-T3007-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3649

Application*: F, MC

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYJT-3648) (CBMAB-T3005-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3648

Application*: EC, F

Rabbit Anti-TNFRSF10A Recombinant Antibody (CBYJT-3647) (CBMAB-T3004-YJ)

SDS

Target: TNFRSF10A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3647

Application*: E, ED

Mouse Anti-TNFRSF10A Recombinant Antibody (CBWJC-4514) (CBMAB-C5907WJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4514

Application*: E

Mouse Anti-TNFRSF10A Recombinant Antibody (CBWJC-4513) (CBMAB-C5906WJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4513

Application*: IP, WB

Mouse Anti-TNFRSF10A Recombinant Antibody (DR-4-02) (CBMAB-C2147-CQ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DR-4-02

Application*: F

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYJT-3652) (CBMAB-T3012-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3652

Application*: F, IC, IF, IP, FN, IF, MC

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYJT-3651) (CBMAB-T3009-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3651

Application*: WB, IP

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYJT-3650) (CBMAB-T3008-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3650

Application*: WB

Mouse Anti-TNFRSF10A Recombinant Antibody (S35-934) (CBMAB-C12542-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: S35-934

Application*: F

Mouse Anti-TNFRSF10A Recombinant Antibody (TR1.02) (CBMAB-T3014-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: TR1.02

Application*: F, IH, WB

Mouse Anti-TNFRSF10A Recombinant Antibody (HS101) (CBMAB-T3013-YJ)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: HS101

Application*: F, FN, IC, IP

Mouse Anti-TNFRSF10A Recombinant Antibody (10B1165) (CBMAB-D2280-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B1165

Application*: F, IP

Mouse Anti-TNFRSF10A Recombinant Antibody (2E8) (CBMAB-D2281-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E8

Application*: E, WB

Mouse Anti-TNFRSF10A Recombinant Antibody (32A1380) (CBMAB-D2282-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 32A1380

Application*: WB

Mouse Anti-TNFRSF10A Recombinant Antibody (32A242) (CBMAB-D2283-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 32A242

Application*: IC, IF, WB

Mouse Anti-TNFRSF10A Recombinant Antibody (6D46) (CBMAB-D2284-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D46

Application*: F, IC, IP

Mouse Anti-TNFRSF10A Recombinant Antibody (8Y3) (CBMAB-D2285-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8Y3

Application*: F

Mouse Anti-TNFRSF10A Recombinant Antibody (B-N28) (CBMAB-D2286-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-N28

Application*: WB, IP

Mouse Anti-TNFRSF10A Recombinant Antibody (B-N36) (CBMAB-D2287-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-N36

Application*: N, IC, IF

Mouse Anti-TNFRSF10A Recombinant Antibody (CBYCD-515) (CBMAB-D2288-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCD-515

Application*: F, P, N, WB

Rabbit Anti-TNFRSF10A Recombinant Antibody (D9S1R) (CBMAB-D2289-YC)

SDS

Target: TNFRSF10A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D9S1R

Application*: F, IF, IP, WB

Mouse Anti-TNFRSF10A Recombinant Antibody (DR402) (CBMAB-D2290-YC)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: DR402

Application*: IP, FN, F, IC, IF

Mouse Anti-TNFRSF10A Recombinant Antibody (1H7) (CBMAB-A9240-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1H7

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (2B11) (CBMAB-A9241-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2B11

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (2G4) (CBMAB-A9242-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G4

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (3B4) (CBMAB-A9243-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3B4

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (4B8) (CBMAB-A9244-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4B8

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (7A6) (CBMAB-A9245-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 7A6

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (7F8) (CBMAB-A9246-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 7F8

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (8D1) (CBMAB-A9247-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 8D1

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (8F3) (CBMAB-A9248-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 8F3

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (8F4) (CBMAB-A9249-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 8F4

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (1E5) (CBMAB-A9236-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E5

Application*: WB, E

Mouse Anti-TNFRSF10A Recombinant Antibody (2E9) (CBMAB-A9238-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E9

Application*: E, E

Mouse Anti-TNFRSF10A Recombinant Antibody (1A8) (CBMAB-A9239-LY)

SDS

Target: TNFRSF10A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A8

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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