Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761)


See all TNFRSF10A antibodies
Online Inquiry
Tested Data
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in ELISA
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in ELISA
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in WB
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in WB
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in WB
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in WB
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in FC
Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297) (V2LY-0625-LY1761) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3297
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human TNFRSF10A (AA: extra 24-239) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
8797
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.
Topology
Extracellular: 24-239
Helical: 240-262
Cytoplasmic: 263-468
PTM
Palmitoylated (PubMed:19090789).
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TNFRSF10A Recombinant Antibody (CBT3297)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry