Human Recombinant TNFRSF10A protein, hFc Tag (V2LY-0526-LY3640)

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Datasheet
SDS
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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
hFc Tag
Protein Construction
This product is Human Recombinant TNFRSF10A protein, hFc Tag consist of Amino Acid: 1-239 and predicts a molecular mass of 41.3 kDa.
Molecule Mass
41.3 kDa
Sequence
Amino Acid: 1-239
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>92% as determined by SDS-PAGE
Endotoxin
Please contact us for more information.
Format
Lyophilized
Reconstitution
Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.
Buffer
Lyophilized from sterile PBS
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
TNFRSF10A Gene(Protein Coding) TNF Receptor Superfamily Member 10a
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.
Topology
Extracellular: 24-239
Helical: 240-262
Cytoplasmic: 263-468
PTM
Palmitoylated (PubMed:19090789).
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TNFRSF10A protein, His Tag (CAT#: V2LY-0526-LY3641)

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Isotype control

For research use only. Not intended for any clinical use.

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