TNFRSF8 (Concentrate)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Full Name

TNFRSF8 TNF Receptor Superfamily Member 8

Function

Receptor for TNFSF8/CD30L (PubMed:8391931).
May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).

Biological Process

Biological Process cellular response to mechanical stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of TRAIL production Source:UniProtKB1 Publication
Biological Process positive regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Cytoplasm

Topology

Extracellular: 19-385
Helical: 386-406
Cytoplasmic: 407-595

PTM

Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).