TNP1

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM

Full Name

transition protein 1 (during histone to protamine replacement)

Function

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

Biological Process

Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process flagellated sperm motility Source:UniProtKB1 Publication
Biological Process heterochromatin assembly Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process nucleosome disassembly Source:UniProtKB1 Publication
Biological Process positive regulation of protein processing Source:UniProtKB
Biological Process sexual reproduction Source:UniProtKB1 Publication
Biological Process single strand break repair Source:UniProtKB1 Publication
Biological Process spermatid development Source:UniProtKB1 Publication
Biological Process spermatid nucleus differentiation Source:UniProtKB1 Publication
Biological Process spermatid nucleus elongation Source:UniProtKB1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteins Source:UniProtKB

Cellular Location

Nucleus
Chromosome
Loaded onto the nucleosomes of condensing spermatids.