Mouse Anti-TNP1 Recombinant Antibody (1B5) (CBMAB-A9403-LY)

Name: Mouse Anti-TNP1 Recombinant Antibody (1B5)
SKU: CBMAB-A9403-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B5

Application

WB, ELISA

Immunogen

TNP1 (AAH29516.1, 1 a.a. ~ 55 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

transition protein 1 (during histone to protamine replacement)

Introduction

Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM

Entrez Gene ID

7141

UniProt ID

P09430

Alternative Names

TP1

Function

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

Biological Process

Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process flagellated sperm motility Source:UniProtKB1 Publication
Biological Process heterochromatin assembly Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process nucleosome disassembly Source:UniProtKB1 Publication
Biological Process positive regulation of protein processing Source:UniProtKB
Biological Process sexual reproduction Source:UniProtKB1 Publication
Biological Process single strand break repair Source:UniProtKB1 Publication
Biological Process spermatid development Source:UniProtKB1 Publication
Biological Process spermatid nucleus differentiation Source:UniProtKB1 Publication
Biological Process spermatid nucleus elongation Source:UniProtKB1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteins Source:UniProtKB

Cellular Location

Nucleus
Chromosome
Loaded onto the nucleosomes of condensing spermatids.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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