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Mouse Anti-TNP1 Recombinant Antibody (1B5) (CBMAB-A9403-LY)

The product is antibody recognizes TNP1. The antibody 1B5 immunoassay techniques such as: WB, ELISA.
See all TNP1 antibodies
Published Data
Fig.1 Characterization of cultured human testicular tissue after thaw.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TNP1 (AAH29516.1, 1 a.a. ~ 55 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
transition protein 1 (during histone to protamine replacement)
Introduction
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM
Entrez Gene ID
7141
UniProt ID
P09430
Alternative Names
TP1
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Biological Process
Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process flagellated sperm motility Source:UniProtKB1 Publication
Biological Process heterochromatin assembly Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process nucleosome disassembly Source:UniProtKB1 Publication
Biological Process positive regulation of protein processing Source:UniProtKB
Biological Process sexual reproduction Source:UniProtKB1 Publication
Biological Process single strand break repair Source:UniProtKB1 Publication
Biological Process spermatid development Source:UniProtKB1 Publication
Biological Process spermatid nucleus differentiation Source:UniProtKB1 Publication
Biological Process spermatid nucleus elongation Source:UniProtKB1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteins Source:UniProtKB
Cellular Location
Nucleus
Chromosome
Loaded onto the nucleosomes of condensing spermatids.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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