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Mouse Anti-TNP1 Recombinant Antibody (CBYJT-4113) (CBMAB-T3552-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNP1 (Transition Protein 1). The antibody can be used for immunoassay techniques, such as ELISA, IHC, WB.
See all TNP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4113
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-55 from human TNP (AAH29516)1 with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-55

Target

Full Name
transition protein 1 (during histone to protamine replacement)
Introduction
Transition protein-1 (TNP1) is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (Luerssen et al., 1990 [PubMed 2249851]).
Entrez Gene ID
7141
UniProt ID
P09430
Alternative Names
Transition Protein 1; Transition Protein 1 (During Histone To Protamine Replacement); Spermatid Nuclear Transition Protein 1; STP-1; TP-1; TP1
Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Biological Process
Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process flagellated sperm motility Source:UniProtKB1 Publication
Biological Process heterochromatin assembly Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process nucleosome disassembly Source:UniProtKB1 Publication
Biological Process positive regulation of protein processing Source:UniProtKB
Biological Process sexual reproduction Source:UniProtKB1 Publication
Biological Process single strand break repair Source:UniProtKB1 Publication
Biological Process spermatid development Source:UniProtKB1 Publication
Biological Process spermatid nucleus differentiation Source:UniProtKB1 Publication
Biological Process spermatid nucleus elongation Source:UniProtKB1 Publication
Biological Process spermatogenesis, exchange of chromosomal proteins Source:UniProtKB
Cellular Location
Nucleus
Chromosome
Loaded onto the nucleosomes of condensing spermatids.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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