TOP1MT

TOP1MT is a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. TOP1MT is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription.
Full Name
DNA Topoisomerase I Mitochondrial
Function
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).
Biological Process
Biological Process DNA replication Source:GO_Central1 Publication
Biological Process DNA topological change Source:GO_Central1 Publication
Cellular Location
Mitochondrion
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Anti-TOP1MT antibodies

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Mouse Anti-TOP1MT Recombinant Antibody (TPIMT-1) (CBMAB-T3656-YJ)

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Target: TOP1MT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: TPIMT-1
Application*: IF, P
Datasheet SDS

Mouse Anti-TOP1MT Antibody (12BA4) (CBMAB-1693CQ)

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Target: TOP1MT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA4
Application*: IH, IF
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Mouse Anti-TOP1MT Antibody (12BA3) (CBMAB-1692CQ)

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Target: TOP1MT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12BA3
Application*: IH, IF
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Mouse Anti-TOP1MT Antibody (12BA2) (CBMAB-1691CQ)

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Target: TOP1MT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 12BA2
Application*: IH, IF
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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