TP53I3

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Full Name
TP53I3 Gene(Protein Coding) Tumor Protein P53 Inducible Protein 3
Function
Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281).
Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281).
Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281).
Biological Process
Biological Process NADP metabolic process Source:UniProtKB1 Publication
Cellular Location
Cytosol
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Anti-TP53I3 antibodies

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Mouse Anti-TP53I3 Recombinant Antibody (3B11) (CBMAB-P3734-YC)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B11
Application*: WB, P
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (1C9) (CBMAB-P3733-YC)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C9
Application*: WB, F, E
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (10A2) (CBMAB-P3732-YC)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A2
Application*: WB
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (AT1C9) (CBMAB-T3749-YJ)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AT1C9
Application*: F, E, WB
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4273) (CBMAB-T3748-YJ)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4273
Application*: WB
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4272) (CBMAB-T3747-YJ)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4272
Application*: WB, IH
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4271) (CBMAB-T3746-YJ)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4271
Application*: E, WB
Datasheet SDS

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4270) (CBMAB-T3745-YJ)

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Target: TP53I3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4270
Application*: WB
Datasheet SDS

TP53I3 Matched Antibody Pair (1256) (APMAB-1256LY)

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Target: TP53I3
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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