Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4272) (CBMAB-T3747-YJ)

Name: Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4272)
SKU: CBMAB-T3747-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4272

Application

WB, IHC

Immunogen

Full length human recombinant protein of human TP53I3(NP_671713) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TP53I3 Gene(Protein Coding) Tumor Protein P53 Inducible Protein 3

Introduction

TP53I3 is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer.

Entrez Gene ID

9540

UniProt ID

Q53FA7

Alternative Names

Tumor Protein P53 Inducible Protein 3; P53-Induced Gene 3 Protein; PIG3; Tumor Protein P53-Inducible Protein 3; Quinone Oxidoreductase Homolog; Quinone Oxidoreductase PIG3

Function

Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281).
Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281).
Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281).

Biological Process

Biological Process NADP metabolic process Source:UniProtKB1 Publication

Cellular Location

Cytosol

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TP53I3 Matched Antibody Pair (1256) (CAT#: APMAB-1256LY)

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Mouse Anti-TP53I3 Recombinant Antibody (3B11) (CAT#: CBMAB-P3734-YC)

Mouse Anti-TP53I3 Recombinant Antibody (1C9) (CAT#: CBMAB-P3733-YC)

TP53I3 Matched Antibody Pair (1256) (CAT#: APMAB-1256LY)

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4271) (CAT#: CBMAB-T3746-YJ)

Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4273) (CAT#: CBMAB-T3748-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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