TRAF3IP2

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq]

TRAF3 interacting protein 2

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828).
Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828).
Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361).
Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).

Biological Process B cell affinity maturation Source:Ensembl
Biological Process B cell apoptotic process Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process CD40 signaling pathway Source:Ensembl
Biological Process eosinophil homeostasis Source:Ensembl
Biological Process eosinophil mediated immunity Source:Ensembl
Biological Process establishment of T cell polarity Source:Ensembl
Biological Process heart development Source:Ensembl
Biological Process humoral immune response Source:GO_Central1 Publication
Biological Process inflammatory response Source:MGI1 Publication
Biological Process interleukin-17-mediated signaling pathway Source:UniProtKB2 Publications
Biological Process interleukin-17A-mediated signaling pathway Source:MGI1 Publication
Biological Process intracellular signal transduction Source:UniProtKB1 Publication
Biological Process kidney development Source:Ensembl
Biological Process leukocyte activation involved in inflammatory response Source:Ensembl
Biological Process lymph node development Source:Ensembl
Biological Process mRNA stabilization Source:Ensembl
Biological Process mucus secretion Source:Ensembl
Biological Process neutrophil activation Source:Ensembl
Biological Process positive regulation of defense response to virus by host Source:CACAO1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process protein import into nucleus Source:Ensembl
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein localization to P-body Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction involved in regulation of gene expression Source:Ensembl
Biological Process skin development Source:Ensembl
Biological Process spleen development Source:Ensembl
Biological Process T cell differentiation Source:Ensembl
Biological Process T-helper 17 type immune response Source:Ensembl
Biological Process transitional two stage B cell differentiation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Biological Process type 2 immune response Source:Ensembl

cytoplasmic vesicle
nucleus

Psoriasis 13 (PSORS13):
A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Candidiasis, familial, 8 (CANDF8):
A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.