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Rat Anti-TRAF3IP2 Recombinant Antibody (9TRAF3IP22) (CBMAB-A0776-YC)

Provided herein is a Rat monoclonal antibody against Human TNF receptor associated factor 3. The antibody can be used for immunoassay techniques, such as WB.
See all TRAF3IP2 antibodies
Published Data
Fig.1 Act1 interacts with IKKε and IRF3 via
distinct regions
...View More
Fig.2 Proteins in the lysates were separated by SDS-PAGE
and analyzed by Western blot (WB) using mAbs against Act1 and b-actin.
...View More

Summary

Host Animal
Rat
Specificity
Human
Clone
9ACT12
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRAF3 interacting protein 2
Introduction
ACT1 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of C
Entrez Gene ID
Human10758
UniProt ID
HumanO43734
Alternative Names
CAP1; LAP1; CAP-1; CRAF1; IIAE5; CD40bp; RNF118; TNF receptor-associated factor 3; CD40 associated protein 1; CD40 binding protein; CD40 receptor associated factor 1; LMP1-associated protein 1; RING-type E3 ubiquitin transferase TRAF3; EC 2.3.2.27
Function
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828).
Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828).
Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361).
Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).
Biological Process
Biological Process B cell affinity maturation Source:Ensembl
Biological Process B cell apoptotic process Source:Ensembl
Biological Process B cell homeostasis Source:Ensembl
Biological Process CD40 signaling pathway Source:Ensembl
Biological Process eosinophil homeostasis Source:Ensembl
Biological Process eosinophil mediated immunity Source:Ensembl
Biological Process establishment of T cell polarity Source:Ensembl
Biological Process heart development Source:Ensembl
Biological Process humoral immune response Source:GO_Central1 Publication
Biological Process inflammatory response Source:MGI1 Publication
Biological Process interleukin-17-mediated signaling pathway Source:UniProtKB2 Publications
Biological Process interleukin-17A-mediated signaling pathway Source:MGI1 Publication
Biological Process intracellular signal transduction Source:UniProtKB1 Publication
Biological Process kidney development Source:Ensembl
Biological Process leukocyte activation involved in inflammatory response Source:Ensembl
Biological Process lymph node development Source:Ensembl
Biological Process mRNA stabilization Source:Ensembl
Biological Process mucus secretion Source:Ensembl
Biological Process neutrophil activation Source:Ensembl
Biological Process positive regulation of defense response to virus by host Source:CACAO1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process protein import into nucleus Source:Ensembl
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein localization to P-body Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process signal transduction involved in regulation of gene expression Source:Ensembl
Biological Process skin development Source:Ensembl
Biological Process spleen development Source:Ensembl
Biological Process T cell differentiation Source:Ensembl
Biological Process T-helper 17 type immune response Source:Ensembl
Biological Process transitional two stage B cell differentiation Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:Ensembl
Biological Process type 2 immune response Source:Ensembl
Cellular Location
cytoplasmic vesicle
nucleus
Involvement in disease
Psoriasis 13 (PSORS13):
A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Candidiasis, familial, 8 (CANDF8):
A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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