TRIM2

TRIM2 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to cytoplasmic filaments. It plays a neuroprotective role and plays a role as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy.
Full Name
Tripartite Motif Containing 2
Function
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of neuron apoptotic process Source:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Charcot-Marie-Tooth disease 2R (CMT2R):
An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
PTM
RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
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Anti-TRIM2 antibodies

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Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4693) (CBMAB-T4229-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBYJT-4693
Application*: F, WB
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4692) (CBMAB-T4228-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4692
Application*: WB
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4691) (CBMAB-T4227-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4691
Application*: F, WB
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4690) (CBMAB-T4226-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4690
Application*: WB, IF
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4689) (CBMAB-T4225-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4689
Application*: F, WB
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4688) (CBMAB-T4224-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4688
Application*: F, WB
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4687) (CBMAB-T4223-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4687
Application*: WB, F
Datasheet SDS

Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4686) (CBMAB-T4222-YJ)

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Target: TRIM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4686
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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