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Mouse Anti-TRIM2 Recombinant Antibody (CBYJT-4686) (CBMAB-T4222-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM2 (Tripartite Motif Containing 2). The antibody can be used for immunoassay techniques, such as WB, FC.
See all TRIM2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4686
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 1-100 and 645-744 of human TRIM2 (NP_056086) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-100, 645-744

Target

Full Name
Tripartite Motif Containing 2
Introduction
TRIM2 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to cytoplasmic filaments. It plays a neuroprotective role and plays a role as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy.
Entrez Gene ID
23321
UniProt ID
Q9C040
Alternative Names
Tripartite Motif Containing 2; RING-Type E3 Ubiquitin Transferase TRIM2; E3 Ubiquitin-Protein Ligase TRIM2; RING Finger Protein 86; RNF86; Tripartite Motif-Containing Protein 2
Function
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of neuron apoptotic process Source:UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Charcot-Marie-Tooth disease 2R (CMT2R):
An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
PTM
RING-type zinc finger-dependent and UBE2D1-dependent autoubiquitination.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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