TRIM36

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
Full Name
tripartite motif-containing 36
Function
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737).
May play a role in the acrosome reaction and fertilization.
Biological Process
Biological Process acrosome reaction Source:GO_Central1 Publication
Biological Process mitotic cytokinesis Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of microtubule cytoskeleton organization Source:UniProtKB1 Publication
Biological Process spindle organization Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Found in the acrosomal region of elongated spermatids and mature sperm.
Involvement in disease
Anencephaly 1 (ANPH1):
An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH1 inheritance is autosomal recessive.
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Anti-TRIM36 antibodies

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Mouse Anti-TRIM36 Recombinant Antibody (1G11) (CBMAB-A9517-LY)

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Target: TRIM36
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G11
Application*: WB, E
Datasheet SDS

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4760) (CBMAB-T4301-YJ)

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Target: TRIM36
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4760
Application*: E, IF, P, WB
Datasheet SDS

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4759) (CBMAB-T4300-YJ)

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Target: TRIM36
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4759
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-TRIM36 Recombinant Antibody (CBCNR-627) (CBMAB-R4076-CN)

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Target: TRIM36
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-627
Application*: WB, P
Datasheet SDS

Mouse Anti-TRIM36 Recombinant Antibody (2D11) (CBMAB-R4075-CN)

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Target: TRIM36
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D11
Application*: E, IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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