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TRIM36

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

Full Name

tripartite motif-containing 36

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737).
May play a role in the acrosome reaction and fertilization.

Biological Process

Biological Process acrosome reaction Source:GO_Central1 Publication
Biological Process mitotic cytokinesis Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of microtubule cytoskeleton organization Source:UniProtKB1 Publication
Biological Process spindle organization Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Found in the acrosomal region of elongated spermatids and mature sperm.

Involvement in disease

Anencephaly 1 (ANPH1):
An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH1 inheritance is autosomal recessive.

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Anti-TRIM36 antibodies

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Mouse Anti-TRIM36 Recombinant Antibody (1G11) (CBMAB-A9517-LY)

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Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1G11

Application*: WB, E

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4760) (CBMAB-T4301-YJ)

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Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4760

Application*: E, IF, P, WB

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4759) (CBMAB-T4300-YJ)

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Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4759

Application*: E, IF, WB

Mouse Anti-TRIM36 Recombinant Antibody (CBCNR-627) (CBMAB-R4076-CN)

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Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-627

Application*: WB, P

Mouse Anti-TRIM36 Recombinant Antibody (2D11) (CBMAB-R4075-CN)

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Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D11

Application*: E, IF, IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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