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TRIM36

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]

Full Name

tripartite motif-containing 36

Function

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737).
May play a role in the acrosome reaction and fertilization.

Biological Process

Biological Process acrosome reaction Source:GO_Central1 Publication
Biological Process mitotic cytokinesis Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of microtubule cytoskeleton organization Source:UniProtKB1 Publication
Biological Process spindle organization Source:UniProtKB1 Publication

Cellular Location

Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Found in the acrosomal region of elongated spermatids and mature sperm.

Involvement in disease

Anencephaly 1 (ANPH1):
An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH1 inheritance is autosomal recessive.

Anti-TRIM36 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-TRIM36 Recombinant Antibody (1G11) (CBMAB-A9517-LY)

SDS

Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1G11

Application*: WB, E

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4760) (CBMAB-T4301-YJ)

SDS

Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4760

Application*: E, IF, P, WB

Mouse Anti-TRIM36 Recombinant Antibody (CBYJT-4759) (CBMAB-T4300-YJ)

SDS

Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4759

Application*: E, IF, WB

Mouse Anti-TRIM36 Recombinant Antibody (CBCNR-627) (CBMAB-R4076-CN)

SDS

Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-627

Application*: WB, P

Mouse Anti-TRIM36 Recombinant Antibody (2D11) (CBMAB-R4075-CN)

SDS

Target: TRIM36

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D11

Application*: E, IF, IH, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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