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Mouse Anti-TRIM36 Recombinant Antibody (1G11) (CBMAB-A9517-LY)

The product is antibody recognizes TRIM36. The antibody 1G11 immunoassay techniques such as: WB, ELISA.
See all TRIM36 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TRIM36 (NP_061170, 391 a.a. ~ 499 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tripartite motif-containing 36
Introduction
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq]
Entrez Gene ID
55521
UniProt ID
Q9NQ86
Alternative Names
HAPRIN; RBCC728; RNF98
Function
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737).
May play a role in the acrosome reaction and fertilization.
Biological Process
Biological Process acrosome reaction Source:GO_Central1 Publication
Biological Process mitotic cytokinesis Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:Ensembl
Biological Process regulation of microtubule cytoskeleton organization Source:UniProtKB1 Publication
Biological Process spindle organization Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cytoplasm, cytoskeleton
Found in the acrosomal region of elongated spermatids and mature sperm.
Involvement in disease
Anencephaly 1 (ANPH1):
An extreme form of neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH1 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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