TRIM54

The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

tripartite motif-containing 54

May bind and stabilize microtubules during myotubes formation.

Biological Process cell differentiation Source:UniProtKB-KW
Biological Process microtubule-based process Source:UniProtKB1 Publication
Biological Process negative regulation of microtubule depolymerization Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process signal transduction Source:UniProtKB1 Publication

Cytoplasm, cytoskeleton
Cytoplasm, myofibril, sarcomere, Z line
Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity).