TRPV3

Trpv3 functions in negative regulation of hair cycle, positive regulation of calcium ion import, response to heat.

Full Name

Transient Receptor Potential Cation Channel, Subfamily V, Member 3

Function

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).

Biological Process

Biological Process calcium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process negative regulation of hair cycle Source:UniProtKB1 Publication
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process response to heat Source:Ensembl

Cellular Location

Membrane

Involvement in disease

Olmsted syndrome (OLMS):
A rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes.
Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2):
A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.

Topology

Cytoplasmic: 1-439
Helical: 440-460
Extracellular: 461-487
Helical: 488-508
Cytoplasmic: 509-523
Helical: 524-544
Extracellular: 545
Helical: 546-566
Cytoplasmic: 567-589
Helical: 590-610
Pore-forming: 621-637
Helical: 650-670
Cytoplasmic: 671-790