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Mouse Anti-Trpv3 Recombinant Antibody (S15-39) (CBMAB-T4480-YJ)

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Basic Information

Host Animal
Mouse
Clone
S15-39
Application
WB, IF, ICC, IP
Immunogen
Synthetic peptide amino acids 458-474 (cytoplasmic C-terminus) of rat TrpV3 accession number NP_001020928)
Specificity
Rat, Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 458-474
More Infomation

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily V, Member 3
Introduction
Trpv3 functions in negative regulation of hair cycle, positive regulation of calcium ion import, response to heat.
Entrez Gene ID
Human162514
Mouse246788
Rat497948
UniProt ID
HumanQ8NET8
MouseQ8K424
RatE9PU00
Alternative Names
transient receptor potential cation channel subfamily V member 3; heat sensitive channel TRPV3
Function
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Biological Process
Biological Process calcium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process negative regulation of hair cycle Source:UniProtKB1 Publication
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process response to heat Source:Ensembl
Cellular Location
Membrane
Involvement in disease
Olmsted syndrome (OLMS):
A rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes.
Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2):
A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.
Topology
Cytoplasmic: 1-439
Helical: 440-460
Extracellular: 461-487
Helical: 488-508
Cytoplasmic: 509-523
Helical: 524-544
Extracellular: 545
Helical: 546-566
Cytoplasmic: 567-589
Helical: 590-610
Pore-forming: 621-637
Helical: 650-670
Cytoplasmic: 671-790
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-TRPV3 Recombinant Antibody (CBYY-1232) (CAT#: CBMAB-1236-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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