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Mouse Anti-TRPV3 Recombinant Antibody (CBYY-1232) (CBMAB-1236-YY)

This product is mouse antibody that recognizes TRPV3. The antibody CBYY-1232 can be used for immunoassay techniques such as: WB, IHC, IP
See all TRPV3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYY-1232
Antibody Isotype
IgG2a
Application
WB, IHC, IP

Basic Information

Specificity
Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transient Receptor Potential Cation Channel, Subfamily V, Member 3
Introduction
This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforMouse have been found for this gene.
Entrez Gene ID
246788
UniProt ID
Q8NET8
Alternative Names
Transient Receptor Potential Cation Channel Subfamily V Member 3; Vanilloid Receptor-Like 3; VRL-3; Transient Receptor Potential Cation Channel, Subfamily V, Member 3; Vanilloid Receptor-Related Osmotically Activated Channel Protein; FNEPPK2; TrpV3; OLMouse; VRL3;
Function
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Biological Process
Biological Process calcium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process calcium ion transmembrane transport Source:Reactome
Biological Process negative regulation of hair cycle Source:UniProtKB1 Publication
Biological Process positive regulation of calcium ion import Source:Ensembl
Biological Process response to heat Source:Ensembl
Cellular Location
Membrane
Involvement in disease
Olmsted syndrome (OLMS):
A rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes.
Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2):
A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction.
Topology
Cytoplasmic: 1-439
Helical: 440-460
Extracellular: 461-487
Helical: 488-508
Cytoplasmic: 509-523
Helical: 524-544
Extracellular: 545
Helical: 546-566
Cytoplasmic: 567-589
Helical: 590-610
Pore-forming: 621-637
Helical: 650-670
Cytoplasmic: 671-790
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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