UBXN2B

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.

UBX Domain Protein 2B

Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156).
Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156).
The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156).
VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156).
Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807).
Also, regulates spindle orientation during mitosis (PubMed:23649807).

Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process establishment of mitotic spindle orientation Source:UniProtKB1 Publication
Biological Process Golgi organization Source:GO_Central1 Publication
Biological Process membrane fusion Source:GO_Central1 Publication
Biological Process negative regulation of protein localization to centrosome Source:UniProtKB1 Publication
Biological Process nuclear membrane reassembly Source:GO_Central1 Publication
Biological Process positive regulation of mitotic centrosome separation Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication

Nucleus
Cytoplasm, cytosol
Endoplasmic reticulum
Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Localizes to centrosome during mitotic prophase and metaphase.