UBXN2B

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
Full Name
UBX Domain Protein 2B
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156).
Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156).
The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156).
VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156).
Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807).
Also, regulates spindle orientation during mitosis (PubMed:23649807).
Biological Process
Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process establishment of mitotic spindle orientation Source:UniProtKB1 Publication
Biological Process Golgi organization Source:GO_Central1 Publication
Biological Process membrane fusion Source:GO_Central1 Publication
Biological Process negative regulation of protein localization to centrosome Source:UniProtKB1 Publication
Biological Process nuclear membrane reassembly Source:GO_Central1 Publication
Biological Process positive regulation of mitotic centrosome separation Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
Endoplasmic reticulum
Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Localizes to centrosome during mitotic prophase and metaphase.
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Anti-UBXN2B antibodies

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Mouse Anti-UBXN2B Recombinant Antibody (3H8) (CBMAB-C4422-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H8
Application*: FC, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (2E9) (CBMAB-C4421-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E9
Application*: IH, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (2E8) (CBMAB-C4420-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E8
Application*: FC, IF, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (1G9) (CBMAB-C4419-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G9
Application*: FC, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (1G8) (CBMAB-C4418-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G8
Application*: FC, IF, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (1G3) (CBMAB-C4417-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G3
Application*: FC, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (1F9) (CBMAB-C4416-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: P, WB
Datasheet SDS

Mouse Anti-UBXN2B Recombinant Antibody (1F7) (CBMAB-C4415-CN)

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Target: UBXN2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F7
Application*: WB, FC, IH, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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