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Mouse Anti-UBXN2B Recombinant Antibody (1F7) (CBMAB-C4415-CN)

This product is a Mouse antibody that recognizes UBXN2B. The antibody 1F7 can be used for immunoassay techniques such as: WB, FC, IHC, IHC-P.
See all UBXN2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F7
Antibody Isotype
IgG1
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human UBXN2B (NP_001071087) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
UBX Domain Protein 2B
Introduction
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity.
Entrez Gene ID
137886
UniProt ID
Q14CS0
Alternative Names
UBX Domain Protein 2B; NSFL1 Cofactor P37; P97 Cofactor P37; UBX Domain-Containing Protein 2B; P37;
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156).
Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156).
The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156).
VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156).
Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807).
Also, regulates spindle orientation during mitosis (PubMed:23649807).
Biological Process
Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process establishment of mitotic spindle orientation Source:UniProtKB1 Publication
Biological Process Golgi organization Source:GO_Central1 Publication
Biological Process membrane fusion Source:GO_Central1 Publication
Biological Process negative regulation of protein localization to centrosome Source:UniProtKB1 Publication
Biological Process nuclear membrane reassembly Source:GO_Central1 Publication
Biological Process positive regulation of mitotic centrosome separation Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm, cytosol
Endoplasmic reticulum
Golgi apparatus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Localizes to centrosome during mitotic prophase and metaphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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