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USP3

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.

Full Name

ubiquitin specific peptidase 3

Function

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.

Biological Process

Biological Process chromatin organization Source:UniProtKB-KW
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process histone deubiquitination Source:UniProtKB1 Publication
Biological Process mitotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of protein stability Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Nucleus
Localizes preferentially with monoubiquitinated H2A to chromatin.

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Anti-USP3 antibodies

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Recombinant Mouse Anti-USP3 Recombinant Antibody (AE9-12-1) (CBMAB-XB1209-YC)

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Target: USP3

Host: Mouse

Specificity: Human, Mouse

Clone: AE9-12-1

Application*: IP, WB

Mouse Anti-USP3 (aa 421-520) Recombinant Antibody (1H2) (CBMAB-U0039-CQ)

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Target: USP3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1H2

Application*: E, IF, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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