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Mouse Anti-USP3 (aa 421-520) Recombinant Antibody (1H2) (CBMAB-U0039-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H2
Antibody Isotype
IgG2a, к
Application
ELISA, IF, WB

Basic Information

Immunogen
USP3 (NP_006528, 421 a.a. - 520 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 421-520

Target

Full Name
ubiquitin specific peptidase 3
Introduction
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry.
Entrez Gene ID
9960
UniProt ID
Q9Y6I4
Alternative Names
UBP; SIH003
Function
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Biological Process
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process DNA repair Source:UniProtKB1 Publication
Biological Process histone deubiquitination Source:UniProtKB1 Publication
Biological Process mitotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of protein stability Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
Localizes preferentially with monoubiquitinated H2A to chromatin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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