USP33

This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

Full Name

Ubiquitin Specific Peptidase 33

Biological Process

Biological Process axon guidance Source:UniProtKB
Biological Process cell migration Source:UniProtKB
Biological Process cellular response to starvation Source:UniProtKB1 Publication
Biological Process centrosome duplication Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB-KW
Biological Process negative regulation of protein binding Source:UniProtKB1 Publication
Biological Process positive regulation of protein binding Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB4 Publications
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein stabilization Source:CACAO1 Publication
Biological Process regulation of autophagy Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064).
Isoform 3
Golgi apparatus

PTM

Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.