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Mouse Anti-USP33 (aa 327-426) Recombinant Antibody (CBXU-095) (CBMAB-U0194-CQ)

This product is a mouse antibody that recognizes USP33 (aa 327-426). The antibody CBXU-095 can be used for immunoassay techniques such as: ELISA, IF, IHC-P, IP, WB.
See all USP33 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXU-095
Antibody Isotype
IgG1, к
Application
ELISA, IF, IHC-P, IP, WB

Basic Information

Immunogen
USP33 (NP_055832, 327 a.a. - 427 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Concentration
0.5 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 327-426

Target

Full Name
Ubiquitin Specific Peptidase 33
Introduction
This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling.
Entrez Gene ID
23032
UniProt ID
Q8TEY7
Alternative Names
VDU1
Function
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Biological Process
Biological Process axon guidance Source:UniProtKB
Biological Process cell migration Source:UniProtKB
Biological Process cellular response to starvation Source:UniProtKB1 Publication
Biological Process centrosome duplication Source:UniProtKB1 Publication
Biological Process endocytosis Source:UniProtKB-KW
Biological Process negative regulation of protein binding Source:UniProtKB1 Publication
Biological Process positive regulation of protein binding Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB4 Publications
Biological Process protein K48-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein stabilization Source:CACAO1 Publication
Biological Process regulation of autophagy Source:UniProtKB1 Publication
Biological Process regulation of G protein-coupled receptor signaling pathway Source:UniProtKB2 Publications
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064).
Isoform 3
Golgi apparatus
PTM
Ubiquitinated via a VHL-dependent pathway for proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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