VAPB

The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

VAMP Associated Protein B And C

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.

Biological Process cellular calcium ion homeostasis Source:UniProtKB1 Publication
Biological Process COPII-coated vesicle budding Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum membrane organization Source:GO_Central1 Publication
Biological Process endoplasmic reticulum organization Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum unfolded protein response Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum-plasma membrane tethering Source:GO_Central1 Publication
Biological Process IRE1-mediated unfolded protein response Source:UniProtKB1 Publication
Biological Process modulation by host of viral RNA genome replication Source:AgBase
Biological Process negative regulation by host of viral genome replication Source:AgBase
Biological Process negative regulation by virus of viral protein levels in host cell Source:AgBase
Biological Process positive regulation by host of viral genome replication Source:AgBase
Biological Process positive regulation of viral genome replication Source:UniProtKB1 Publication
Biological Process suppression of viral release by host Source:AgBase
Biological Process viral release from host cell Source:AgBase

Endoplasmic reticulum membrane
Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.

Amyotrophic lateral sclerosis 8 (ALS8):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD):
A form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAPAD is characterized by proximal muscle weakness that begins in the lower limbs and then progresses to upper limbs, onset in late adulthood (after third decade) and a benign course. Most of the patients remain ambulatory 10 to 40 years after clinical onset.

Cytoplasmic: 2-222
Helical: 223-243