VIP

The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]

Full Name

Vasoactive Intestinal Peptide

Function

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathway Source:BHF-UCL1 Publication
Biological Process antibacterial humoral response Source:UniProtKB
Biological Process antifungal humoral response Source:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptide Source:UniProtKB
Biological Process body fluid secretion Source:ProtInc1 Publication
Biological Process defense response to Gram-negative bacterium Source:UniProtKB
Biological Process defense response to Gram-positive bacterium Source:UniProtKB
Biological Process epinephrine secretion Source:GO_Central1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB
Biological Process learning or memory Source:GO_Central1 Publication
Biological Process mRNA stabilization Source:AgBase
Biological Process negative regulation of apoptotic process Source:GO_Central1 Publication
Biological Process negative regulation of potassium ion transport Source:GO_Central1 Publication
Biological Process negative regulation of smooth muscle cell proliferation Source:GO_Central1 Publication
Biological Process phospholipase C-activating G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of endothelial cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of epinephrine secretion Source:GO_Central1 Publication
Biological Process positive regulation of penile erection Source:GO_Central1 Publication
Biological Process positive regulation of protein catabolic process Source:BHF-UCL1 Publication
Biological Process prolactin secretion Source:AgBase
Biological Process regulation of protein localization Source:BHF-UCL1 Publication
Biological Process regulation of sensory perception of pain Source:GO_Central1 Publication
Biological Process response to yeast Source:UniProtKB

Cellular Location

Secreted