VPS72

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Full Name

vacuolar protein sorting 72 homolog (S. cerevisiae)

Function

Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

Biological Process

Biological Process histone acetylation Source:ComplexPortal1 Publication
Biological Process histone H2A acetylation Source:ComplexPortal1 Publication
Biological Process histone H4 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of double-strand break repair via homologous recombination Source:ComplexPortal1 Publication
Biological Process regulation of apoptotic process Source:ComplexPortal1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of double-strand break repair Source:ComplexPortal1 Publication
Biological Process somatic stem cell population maintenance Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication

Cellular Location

Nucleus

PTM

Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.