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Mouse Anti-VPS72 Recombinant Antibody (CBLY2-121) (CBMAB-Y0074-LY)

This product is antibody recognizes VPS72. The antibody CBLY2-121 immunoassay techniques such as: WB, ICC/IF.
See all VPS72 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLY2-121
Antibody Isotype
IgG2a
Application
WB, ICC/IF

Basic Information

Immunogen
Human VPS72
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
vacuolar protein sorting 72 homolog (S. cerevisiae)
Introduction
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AFZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Entrez Gene ID
UniProt ID
Alternative Names
YL1; CFL1; Swc2; YL-1; TCFL1
Function
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Biological Process
Biological Process histone acetylation Source:ComplexPortal1 Publication
Biological Process histone H2A acetylation Source:ComplexPortal1 Publication
Biological Process histone H4 acetylation Source:ComplexPortal1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ProtInc1 Publication
Biological Process positive regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process positive regulation of double-strand break repair via homologous recombination Source:ComplexPortal1 Publication
Biological Process regulation of apoptotic process Source:ComplexPortal1 Publication
Biological Process regulation of cell cycle Source:ComplexPortal1 Publication
Biological Process regulation of DNA-templated transcription Source:ComplexPortal1 Publication
Biological Process regulation of double-strand break repair Source:ComplexPortal1 Publication
Biological Process somatic stem cell population maintenance Source:Ensembl
Biological Process transcription initiation-coupled chromatin remodeling Source:UniProtKB1 Publication
Cellular Location
Nucleus
PTM
Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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