WDR77/MEP50

Full Name

WDR77/MEP50

Function

Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452).
This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334).

Biological Process

Biological Process epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process histone H4-R3 methylation Source:ComplexPortal1 Publication
Biological Process negative regulation of epithelial cell proliferation involved in prostate gland development Source:Ensembl
Biological Process oocyte axis specification Source:GO_Central1 Publication
Biological Process positive regulation of cell population proliferation Source:Ensembl
Biological Process positive regulation of mRNA splicing, via spliceosome Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Source:Ensembl
Biological Process spliceosomal snRNP assembly Source:ComplexPortal1 Publication

Cellular Location

Nucleus
Cytoplasm
Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors (PubMed:17437848).