WNK3

Members of the 'with no lysine' (WNK) kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function (Holden et al., 2004 [PubMed 15194194]).[supplied by OMIM

Full Name

WNK lysine deficient protein kinase 3

Function

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011).
Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca2+ influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590).
Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.

Biological Process

Biological Process cell volume homeostasis Source:ARUK-UCL1 Publication
Biological Process intracellular signal transduction Source:UniProtKB
Biological Process ion homeostasis Source:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrier Source:ARUK-UCLBy Similarity
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of sodium ion transport Source:GO_Central1 Publication
Biological Process osmosensory signaling pathway Source:ARUK-UCL1 Publication
Biological Process peptidyl-threonine phosphorylation Source:ARUK-UCLBy Similarity
Biological Process positive regulation of calcium ion transport Source:UniProtKB1 Publication
Biological Process positive regulation of ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of potassium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process positive regulation of protein localization to plasma membrane Source:BHF-UCL1 Publication
Biological Process positive regulation of sodium ion transmembrane transporter activity Source:UniProtKB1 Publication
Biological Process positive regulation of sodium ion transport Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:BHF-UCL1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB
Biological Process regulation of calcium ion import Source:UniProtKB1 Publication
Biological Process regulation of cation transmembrane transport Source:ARUK-UCL1 Publication

Cellular Location

Cytoplasm

PTM

Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation.