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Mouse Anti-WNK3 Recombinant Antibody (4H5) (CBMAB-W0120-WJ)

This product is a mouse antibody that recognizes WNK3. The antibody 4H5 can be used for immunoassay techniques such as: ELISA, WB.
See all WNK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H5
Antibody Isotype
IgG2b, Κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WNK lysine deficient protein kinase 3
Introduction
WNK3 is a protein-coding gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Diseases associated with WNK3 include Syndromic X-Linked Intellectual Disability Siderius Type and Lung Large Cell Carcinoma. An important paralog of this gene is WNK2.
Entrez Gene ID
65267
UniProt ID
Q9BYP7
Alternative Names
PRKWNK3
Function
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011).
Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca2+ influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590).
Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
Biological Process
Biological Process cell volume homeostasis Source:ARUK-UCL1 Publication
Biological Process intracellular signal transduction Source:UniProtKB
Biological Process ion homeostasis Source:UniProtKB1 Publication
Biological Process maintenance of blood-brain barrier Source:ARUK-UCLBy Similarity
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of sodium ion transport Source:GO_Central1 Publication
Biological Process osmosensory signaling pathway Source:ARUK-UCL1 Publication
Biological Process peptidyl-threonine phosphorylation Source:ARUK-UCLBy Similarity
Biological Process positive regulation of calcium ion transport Source:UniProtKB1 Publication
Biological Process positive regulation of ion transmembrane transporter activity Source:BHF-UCL1 Publication
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of potassium ion import across plasma membrane Source:GO_Central1 Publication
Biological Process positive regulation of protein localization to plasma membrane Source:BHF-UCL1 Publication
Biological Process positive regulation of sodium ion transmembrane transporter activity Source:UniProtKB1 Publication
Biological Process positive regulation of sodium ion transport Source:BHF-UCL1 Publication
Biological Process protein autophosphorylation Source:BHF-UCL1 Publication
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB
Biological Process regulation of calcium ion import Source:UniProtKB1 Publication
Biological Process regulation of cation transmembrane transport Source:ARUK-UCL1 Publication
Cellular Location
Cytoplasm
PTM
Ubiquitinated by the BCR(KLHL2) complex, leading to its degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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