WNT16

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. Diseases associated with WNT16 include Nodular Basal Cell Carcinoma and Basal Cell Carcinoma. An important paralog of this gene is WNT7B.

Full Name

Wnt family member 16

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Biological Process

Biological Process bone remodeling Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cardiac epithelial to mesenchymal transition Source:Ensembl
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process keratinocyte differentiation Source:BHF-UCL1 Publication
Biological Process keratinocyte proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cell death Source:BHF-UCL1 Publication
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process optic cup formation involved in camera-type eye development Source:BHF-UCLBy Similarity
Biological Process oxidative stress-induced premature senescence Source:BHF-UCL1 Publication
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of JNK cascade Source:BHF-UCL1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:BHF-UCL1 Publication
Biological Process replicative senescence Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.