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Mouse Anti-WNT16 Recombinant Antibody (CBWJW-126) (CBMAB-W0275-WJ)

This product is a mouse antibody that recognizes WNT16. The antibody CBWJW-126 can be used for immunoassay techniques such as: ICC.
See all WNT16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJW-126
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Wnt-16, Asn30-Lys365.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Wnt family member 16
Introduction
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. Diseases associated with WNT16 include Nodular Basal Cell Carcinoma and Basal Cell Carcinoma. An important paralog of this gene is WNT7B.
Entrez Gene ID
51384
UniProt ID
Q9UBV4
Alternative Names
WNT16; Wnt family member 16
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Biological Process
Biological Process bone remodeling Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cardiac epithelial to mesenchymal transition Source:Ensembl
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process keratinocyte differentiation Source:BHF-UCL1 Publication
Biological Process keratinocyte proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cell death Source:BHF-UCL1 Publication
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process optic cup formation involved in camera-type eye development Source:BHF-UCLBy Similarity
Biological Process oxidative stress-induced premature senescence Source:BHF-UCL1 Publication
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of JNK cascade Source:BHF-UCL1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:BHF-UCL1 Publication
Biological Process replicative senescence Source:BHF-UCL1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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