Mouse Anti-WNT16 Recombinant Antibody (CBWJW-126) (CBMAB-W0275-WJ)

Name: Mouse Anti-WNT16 Recombinant Antibody (CBWJW-126)
SKU: CBMAB-W0275-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBWJW-126

Application

ICC

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Wnt-16, Asn30-Lys365.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Wnt family member 16

Introduction

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. Diseases associated with WNT16 include Nodular Basal Cell Carcinoma and Basal Cell Carcinoma. An important paralog of this gene is WNT7B.

Entrez Gene ID

51384

UniProt ID

Q9UBV4

Alternative Names

WNT16; Wnt family member 16

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Biological Process

Biological Process bone remodeling Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cardiac epithelial to mesenchymal transition Source:Ensembl
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process keratinocyte differentiation Source:BHF-UCL1 Publication
Biological Process keratinocyte proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cell death Source:BHF-UCL1 Publication
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process optic cup formation involved in camera-type eye development Source:BHF-UCLBy Similarity
Biological Process oxidative stress-induced premature senescence Source:BHF-UCL1 Publication
Biological Process positive regulation of gene expression Source:BHF-UCL1 Publication
Biological Process positive regulation of JNK cascade Source:BHF-UCL1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:BHF-UCL1 Publication
Biological Process replicative senescence Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-WNT16 Recombinant Antibody (CBWJW-164) (CAT#: CBMAB-W0308-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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