WNT8A

WNT8A is a protein-coding gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. An important paralog of this gene is WNT8B.

Full Name

Wnt family member 8A

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.

Biological Process

Biological Process anterior/posterior axis specification Source:ARUK-UCL
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in neural crest cell differentiation Source:BHF-UCL
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process neural crest cell fate commitment Source:BHF-UCL
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process secondary palate development Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix
Secreted

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.