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Rat Anti-WNT8A Recombinant Antibody (38L1) (CBMAB-W0083-WJ)

This product is a rat antibody that recognizes WNT8A. The antibody 38L1 can be used for immunoassay techniques such as: WB.
See all WNT8A antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
38L1
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Wnt family member 8A
Introduction
WNT8A is a protein-coding gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. An important paralog of this gene is WNT8B.
Entrez Gene ID
20890
UniProt ID
Q64527
Alternative Names
WNT8D
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.
Biological Process
Biological Process anterior/posterior axis specification Source:ARUK-UCL
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in neural crest cell differentiation Source:BHF-UCL
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process neural crest cell fate commitment Source:BHF-UCL
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process secondary palate development Source:BHF-UCL1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Secreted
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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