Rat Anti-WNT8A Recombinant Antibody (CBWJW-098) (CBMAB-W0249-WJ)

Name: Rat Anti-WNT8A Recombinant Antibody (CBWJW-098)
SKU: CBMAB-W0249-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBWJW-098

Application

WB, ELISA

Specificity

Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Wnt family member 8A

Introduction

WNT8A is a protein-coding gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. An important paralog of this gene is WNT8B.

Entrez Gene ID

20890

UniProt ID

Q64527

Alternative Names

WNT8D

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.

Biological Process

Biological Process anterior/posterior axis specification Source:ARUK-UCL
Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in neural crest cell differentiation Source:BHF-UCL
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process neural crest cell fate commitment Source:BHF-UCL
Biological Process neuron differentiation Source:GO_Central1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL
Biological Process response to retinoic acid Source:BHF-UCL1 Publication
Biological Process secondary palate development Source:BHF-UCL1 Publication

Cellular Location

Secreted, extracellular space, extracellular matrix
Secreted

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity).
Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Rat Anti-WNT8A Recombinant Antibody (38L1) (CAT#: CBMAB-W0083-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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