YTHDC1

YTHDC1 (YTH Domain Containing 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include N6-methyladenosine-containing RNA binding.

Full Name

YTH Domain Containing 1

Function

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244).
M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451).
Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937).
Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).
In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).
May also regulate alternative splice site selection (PubMed:20167602).
Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).
Also recognizes and binds m6A on other RNA molecules (PubMed:27602518).
Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518).
Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306).
Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).

Biological Process

Biological Process dosage compensation by inactivation of X chromosome Source:UniProtKB1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process mRNA alternative polyadenylation Source:Ensembl
Biological Process mRNA export from nucleus Source:UniProtKB1 Publication
Biological Process mRNA splice site selection Source:UniProtKB1 Publication
Biological Process mRNA splicing, via spliceosome Source:GO_Central1 Publication
Biological Process post-transcriptional regulation of gene expression Source:UniProtKB
Biological Process primary follicle stage Source:Ensembl
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:GO_Central1 Publication
Biological Process regulation of mRNA splicing, via spliceosome Source:UniProtKB2 Publications
Biological Process spermatogenesis Source:Ensembl

Cellular Location

Nucleus
Nucleus speckle
Localizes to a novel subnuclear structure, the YT bodies.

PTM

Tyrosine phosphorylated.