YTHDC1

YTHDC1 (YTH Domain Containing 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include N6-methyladenosine-containing RNA binding.

YTH Domain Containing 1

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244).
M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451).
Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937).
Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).
In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).
May also regulate alternative splice site selection (PubMed:20167602).
Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).
Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity).
Also recognizes and binds m6A on other RNA molecules (PubMed:27602518).
Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist (PubMed:27602518).
Also recognizes and binds m6A-containing single-stranded DNA (PubMed:32663306).
Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity).

Biological Process dosage compensation by inactivation of X chromosome Source:UniProtKB1 Publication
Biological Process in utero embryonic development Source:Ensembl
Biological Process mRNA alternative polyadenylation Source:Ensembl
Biological Process mRNA export from nucleus Source:UniProtKB1 Publication
Biological Process mRNA splice site selection Source:UniProtKB1 Publication
Biological Process mRNA splicing, via spliceosome Source:GO_Central1 Publication
Biological Process post-transcriptional regulation of gene expression Source:UniProtKB
Biological Process primary follicle stage Source:Ensembl
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:GO_Central1 Publication
Biological Process regulation of mRNA splicing, via spliceosome Source:UniProtKB2 Publications
Biological Process spermatogenesis Source:Ensembl

Nucleus
Nucleus speckle
Localizes to a novel subnuclear structure, the YT bodies.

Tyrosine phosphorylated.