ZCCHC3

ZCCHC3 (Zinc Finger CCHC-Type Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Full Name

zinc finger CCHC-type containing 3

Function

Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424).
Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424).
Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424).
Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424).
Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849).

Biological Process

Biological Process activation of innate immune response Source:UniProtKB2 Publications
Biological Process cellular response to exogenous dsRNA Source:UniProtKB1 Publication
Biological Process defense response to virus Source:GO_Central1 Publication
Biological Process detection of virus Source:UniProtKB2 Publications
Biological Process innate immune response Source:UniProtKB-KW
Biological Process positive regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of type I interferon production Source:GO_Central1 Publication

Cellular Location

Cytoplasm