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Mouse Anti-ZCCHC3 Recombinant Antibody (3B11H2) (CBMAB-Z0123-WJ)

This product is a mouse antibody that recognizes ZCCHC3. The antibody 3B11H2 can be used for immunoassay techniques such as: IHC-P, WB.
See all ZCCHC3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B11H2
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
zinc finger CCHC-type containing 3
Introduction
ZCCHC3 (Zinc Finger CCHC-Type Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
Entrez Gene ID
85364
UniProt ID
Q9NUD5
Alternative Names
C20orf99
Function
Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424).
Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424).
Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424).
Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424).
Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849).
Biological Process
Biological Process activation of innate immune response Source:UniProtKB2 Publications
Biological Process cellular response to exogenous dsRNA Source:UniProtKB1 Publication
Biological Process defense response to virus Source:GO_Central1 Publication
Biological Process detection of virus Source:UniProtKB2 Publications
Biological Process innate immune response Source:UniProtKB-KW
Biological Process positive regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of type I interferon production Source:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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