Mouse Anti-ZCCHC3 Recombinant Antibody (3B11H2) (CBMAB-Z0123-WJ)

Name: Mouse Anti-ZCCHC3 Recombinant Antibody (3B11H2)
SKU: CBMAB-Z0123-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

3B11H2

Application

IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

More Infomation

Target

Full Name

zinc finger CCHC-type containing 3

Introduction

ZCCHC3 (Zinc Finger CCHC-Type Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Entrez Gene ID

85364

UniProt ID

Q9NUD5

Alternative Names

C20orf99

Function

Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424).
Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424).
Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424).
Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424).
Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849).

Biological Process

Biological Process activation of innate immune response Source:UniProtKB2 Publications
Biological Process cellular response to exogenous dsRNA Source:UniProtKB1 Publication
Biological Process defense response to virus Source:GO_Central1 Publication
Biological Process detection of virus Source:UniProtKB2 Publications
Biological Process innate immune response Source:UniProtKB-KW
Biological Process positive regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of type I interferon production Source:GO_Central1 Publication

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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