ZNF365

ZNF365 (Zinc Finger Protein 365) is a Protein Coding gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Diseases associated with ZNF365 include Nephrolithiasis, Uric Acid and Nephrolithiasis. An important paralog of this gene is FBXO41.

zinc finger protein 365

May play a role in uric acid excretion.

Biological Process gamma-tubulin complex localization Source:MGI1 Publication
Biological Process mitotic cytokinesis Source:MGI1 Publication

centrosome

Uric acid nephrolithiasis (UAN):
A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones.